15-deoxy-Δ-12,14-Prostaglandin J2 5mg

15-

deoxy-Δ^12,14-Prostaglandin J₂ (15-deoxy-Δ^12,14-PGJ₂) is formed from PGD₂ by the elimination of two molecules of water. It binds selectively to PPARγ with an EC₅₀ value of 2 µM in a murine chimera system.^1,2 15-deoxy-Δ^12,14-PGJ₂ is more potent than PGD₂, Δ¹²-PGJ₂, and PGJ₂ in stimulating lipogenesis in C3H10T1/2 cells. The EC₅₀ for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.¹

1. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J₂ metabolite binds peroxisome proliferator-activated receptor .gamma. and promotes adipocyte differentiation. Cell 83 813-819 (1995).

2. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-.DELTA.12,14-prostaglandin J₂ is a ligand for the adipocyte determination factor PPAR.gamma.. Cell 83 803-812 (1995).